Dimethyl Sulfoxide → Trametinib Dimethyl Sulfoxide

Participants

Reaction Steps

Dimethyl sulfoxide (3 mL) was added to trametinib (90 mg) at 50° C. with stirring to give a pale yellow solution. The solution was cooled with a rate of 10° C. per hour to 20° C., and then the mixture was stirred at 20° C. for 24 hours, Then the precipitate was collected and dried under reduced pressure at 40° C. for 20 hours to give trametinib dimethyl sulfoxide solvate Form M (75.9 mg, yield 74.8%).

Provenance & Evidence