Dimethyl Sulfoxide → Trametinib Dimethyl Sulfoxide

Participants

Reaction Steps

Dimethyl sulfoxide (2 mL) was added to trametinib (100 mg) at 40° C. with stirring to give a pale yellow solution. The solution was cooled with a rate of 5° C. per hour to 20° C., and the mixture was stirred at 20° C. for 10 hours. Then the precipitate was collected and dried under reduced pressure at 40° C. for 20 hours to give trametinib dimethyl sulfoxide solvate Form M (95.8 mg, yield 85.0%).

Provenance & Evidence