HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 710600Generated: October 29, 2026
Dimethylformamide → 2-Chloronicotinoyl chloride
https://huagongshe.com/reaction/710600
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Chloronicotinic acid | HCID 76258 | — |
| Product | 2-Chloronicotinoyl chloride | HCID 2774541 | — |
Reaction Steps
To 2-chloronicotinic acid (15.7 g, 100 mmol) in thionyl chloride (50 mL) was added DMF (0.2 mL), heated to 70° C. and reacted for 3 h. After reaction was complete, solvent was removed by distillation to obtain crude product 17.5 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09181244B1 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-f146a3d838e9420a9777e7ffb2120167 |
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| Source note | uspto-grants-2015_11 |
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