Isopropyl chloroformate → HCID 118492322, compound

Participants

Reaction Steps

To 1-(3-bromophenyl)-4-oxo-1,4-dihydropyridino[2,3-c]pyridazine-3-carboxylic acid (3.25 g, 9.4 mmol) in dichloromethane (50 mL) was added triethylamine (2.37 g, 23.5 mmol), isopropyl chloroformate (1.49 g, 12.2 mmol), reacted at room temperature for 2 h, cyclopropylamine (0.54 g, 9.4 mmol) was added, reacted at room temperature overnight, extracted with H2O/DCM, organic phase was rotated for dryness to obtain product 3.5 g.

Provenance & Evidence