Isopropyl chloroformate → HCID 72700243, compound

Participants

Reaction Steps

4-oxo-1-(3-(pyridin-3-ylthio)phenyl)-1,4-dihydropyridino[2,3-c]pyridazine-3-carboxylic acid (200 mg, 0.53 mmol) was dissolved in 100 ml of DCM, the following were added dropwise at −15° C. in order: TEA (133.8 mg, 1.325 mmol), isopropyl chlorocarbonate (97 mg, 0.792 mmol), and reacted at −15° C. for 0.5 h, then cyclopropylamine (36 mg, 0.631 mmol) was added dropwise, reacted at room temperature for 3 h. The reaction solution was washed with water, the organic phase was dried, concentrated and crystallized to obtain an object product 13.78 mg.

Provenance & Evidence