HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxypyridine → HCID 72700245, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxypyridine | HCID 7971 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Ethyl 2-oxocyclopentanecarboxylate | HCID 69136 | — |
| Reactant | HCID 72700164 | HCID 72700164 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 72700245 | HCID 72700245 | — |
Reaction Steps
To N-cyclopropyl-4-oxo-1-[3-(pyridin-3-ylethynyl)phenyl]-1,4-dihydropyridino[2,3-c]pyridazine-3-formamide in 50 mL of DMSO was added in sequence 3-hydroxypyridine (0.48 g, 5 mmol), 2-oxocyclopentylcarboxylic acid ethyl ester (0.3 g, 2 mmol), CuI (0.4 g, 2 mmol), Cs2CO3 (2.6 g, 8 mmol), reacted in microwave reactor at 120° C. for 6 h. After reaction was complete, extraction was performed with H2O/DCM, and organic phase was separated to obtain product 26 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181244B1 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-ea9bb00c25524a18b4de8c8c594dc231 |
| Source note | uspto-grants-2015_11 |