Hydrochloric Acid → HCID 73335726, compound

Participants

Reaction Steps

A portion of 1-[1-(4-fluorophenyl)-6,7-dihydro-5H-pyrazolo[4,3-b]pyridin-4-yl]-2-[3-(1-hydroxy-1-methyl-ethyl)-5-methyl-pyrazol-1-yl]butan-1-one was treated with 6 M HCl until complete. The reaction slurry was purified by reverse phase HPLC (C18 column, acetonitrile-H2O with 0.1% TFA as eluent) to provide 12 mg of the title compound as an off-white solid. 1H NMR (400 MHz, CDCl3) δ 8.47 (s, 1H), 7.44 (m, 2H), 7.14 (t, J=8.6 Hz, 2H), 6.14 (s, 1H), 5.42 (br s, 1H), 5.22 (dd, J=7.1, 8.2 Hz, 1H), 5.02 (br s, 1H), 3.80 (ddd, J=3.1, 7.8, 10.1 Hz, 1H), 3.47 (ddd, J=2.8, 9.0, 12.1 Hz, 1H), 2.74 (m, 2H), 2.33 (m, 1H), 2.23 (s, 3H), 2.15 (m, 1H), 2.10 (s, 3H) 1.87 (m, 1H), 1.78 (m, 1H), 0.98 (t, J=7.4 Hz, 3H); MS: (ES) m/z calculated for C23H27FN5O [M+H]+ 408.2, found 408.2.

Provenance & Evidence