HuagongsheHuagongshe Chemistry Print Report · For research reference only
Styrene → 2,3,4,5-tetrahydro-2-methyl-5-phenethyl-1H-pyrido[4,3-b]indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Styrene | HCID 7501 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-methyl-2,3,4,5-tetrahydro-1H-pyrido(4,3-b)indole | HCID 97424 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2,3,4,5-tetrahydro-2-methyl-5-phenethyl-1H-pyrido[4,3-b]indole | HCID 44126268 | — |
Reaction Steps
The title compound was prepared according to General Method 2. 2,3,4,5-Tetrahydro-2-methyl-5-phenethyl-1H-pyrido[4,3-b]indole was prepared from 2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole (200 mg, 1.07), styrene (1.23 mL mmol, 10.65) and NaH (250 mg, 6.25 mmol) in DMF (6 ml) at 200° C. for 16 h to obtain 15 mg of 2,3,4,5-tetrahydro-2-methyl-5-phenethyl-1H-pyrido[4,3-b]indole after purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181240B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-618896771cf943b9ae047afb908bcda0 |
| Source note | uspto-grants-2015_11 |