Styrene → 2-ethyl-2,3,4,5-tetrahydro-5-phenethyl-1H-pyrido[4,3-b]indole

Participants

Role	Name	HCID	Charge
Reactant	Styrene	HCID 7501	—
Reactant	Sodium hydride	HCID 24758	—
Reactant	2-Ethyl-2,3,4,5-tetrahydro-1H-pyrido(4,3-b)indole	HCID 588824	—
Solvent	Dimethylformamide	HCID 6228	—
Product	2-ethyl-2,3,4,5-tetrahydro-5-phenethyl-1H-pyrido[4,3-b]indole	HCID 57875993	9.9%

Reaction Steps

The title compound was prepared according to General Method 2. 2-Ethyl-2,3,4,5-tetrahydro-5-phenethyl-1H-pyrido[4,3-b]indole was prepared from 2-ethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (See Example 5) (100 mg, 0.5 mmol), styrene (1 mL, 8.64 mmol) and NaH (200 mg, 5 mmol) in DMF (4 ml) at 150° C. for 16 h to obtain 15 mg of 2-ethyl-2,3,4,5-tetrahydro-5-phenethyl-1H-pyrido[4,3-b]indole after purification.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09181240B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-c5f33f015e484e20bf884c8448f30f8e
Source note	uspto-grants-2015_11