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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 710759Generated: October 29, 2026

2-Methyl-5-vinylpyridine → HCID 57876097, compound

https://huagongshe.com/reaction/710759

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-5-vinylpyridineHCID 8817—
ReactantPotassium HydroxideHCID 14797—
ReactantHCID 68760131HCID 68760131—
SolventN-methyl-2-pyrrolidoneHCID 13387—
ProductHCID 57876097HCID 57876097—

Reaction Steps

The title compound is prepared from a mixture of 2-(4-(difluoromethyl)phenyl)-2,3,4,5-tetrahydro-8-methyl-1H-pyrido[4,3-b]indole, 2-methyl-5-vinylpyridine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09181240B2
Source datasetuspto-grants-2015_11
ORD IDord-8313dd0e244d4765983ee3de7ce4f35f
Source noteuspto-grants-2015_11