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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 710842Generated: October 30, 2026

Potassium Hydroxide → HCID 57876407, compound

https://huagongshe.com/reaction/710842

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium HydroxideHCID 14797—
Reactant1H-Pyrido[4,3-b]indole, 2,3,4,5-tetrahydro-2,8-dimethyl-HCID 209291—
ReactantHCID 68735228HCID 68735228—
SolventN-methyl-2-pyrrolidoneHCID 13387—
ProductHCID 57876407HCID 57876407—

Reaction Steps

The title compound is prepared from a mixture of 2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole, 2-(trifluoromethyl)-5-vinylpyrazine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09181240B2
Source datasetuspto-grants-2015_11
ORD IDord-91cb695d60a74ac39c0f596c348be8df
Source noteuspto-grants-2015_11