HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-(2,6-difluoropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(2,6-difluoropyridin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine | HCID 67440373 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-(2,6-difluoropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine | HCID 67441956 | — |
Reaction Steps
A mixture of EXAMPLE 56A (8.01 g, 21.6 mmol) and 20% aqueous sodium hydroxide (12 mL, 21.6 mmol) in 1,4-dioxane (75 mL) was heated at 50° C. for 90 minutes. The mixture was concentrated and the residue triturated with water, filtered, and concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181246B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-0272b5da270b44f2ad061e3dd1d0b70f |
| Source note | uspto-grants-2015_11 |