HRID710931

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc(-c2cn(S(=O)(=O)c3ccccc3)c3ncccc23)nc(NCc2cccc(OCCCNC(=O)OC(C)(C)C)c2)n1

HCID67440753

未命名化合物

PRODUCTS

生成物

结构：COc1cc(-c2c[nH]c3ncccc23)nc(NCc2cccc(OCCCNC(=O)OC(C)(C)C)c2)n1

HCID67439456

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID14798

Sodium Hydroxide

HNaO

PROCEDURE

实验过程

A mixture of Example 63B (600 mg, 0.93 mmol) in methanol (12 mL) and NaOH aqueous solution (1M, 4 mL) was stirred at room temperature for 16 hours. The mixture was filtered, and the solid was washed with water and dried in vacuo to give the title compound.

WORKUP

后处理

filtrationThe mixture was filtered
washthe solid was washed with water
customdried in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a03b1a7b4049493a97e6cb5fb5fcce7d
来源数据集: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09181246B2
来源说明: uspto-grants-2015_11

反应 SMILES

[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]2[C:17]3[C:12](=[N:13][CH:14]=[CH:15][CH:16]=3)[N:11](S(C3C=CC=CC=3)(=O)=O)[CH:10]=2)[N:6]=[C:5]([NH:27][CH2:28][C:29]2[CH:30]=[C:31]([CH:44]=[CH:45][CH:46]=2)[O:32][CH2:33][CH2:34][CH2:35][NH:36][C:37](=[O:43])[O:38][C:39]([CH3:42])([CH3:41])[CH3:40])[N:4]=1>CO.[OH-].[Na+]>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]2[C:17]3[C:12](=[N:13][CH:14]=[CH:15][CH:16]=3)[NH:11][CH:10]=2)[N:6]=[C:5]([NH:27][CH2:28][C:29]2[CH:30]=[C:31]([CH:44]=[CH:45][CH:46]=2)[O:32][CH2:33][CH2:34][CH2:35][NH:36][C:37](=[O:43])[O:38][C:39]([CH3:42])([CH3:41])[CH3:40])[N:4]=1