HCID 39238208, compound → HCID 72549642, compound

HRID 710994Notes

Reaction equation

HRID 710994 reaction equation
[CH2:1]([O:8][N:9]1[C:15](=[O:16])[N:14]2[CH2:17][C@H:10]1[CH2:11][CH2:12][C@H:13]2[C:18]([OH:20])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:21]([O:25][C:26](=[O:33])[NH:27][CH2:28][CH2:29][CH2:30][O:31][NH2:32])([CH3:24])([CH3:23])[CH3:22]>>[C:21]([O:25][C:26](=[O:33])[NH:27][CH2:28][CH2:29][CH2:30][O:31][NH:32][C:18]([C@@H:13]1[CH2:12][CH2:11][C@@H:10]2[CH2:17][N:14]1[C:15](=[O:16])[N:9]2[O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:20])([CH3:24])([CH3:22])[CH3:23]

Participants

3

Reactant 2

HCID 39238208HCID 39238208, compoundHCID 57389355(2S,5R)-6-(Benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid

Product 1

HCID 72549642HCID 72549642, compoundYield 63%

Procedure

Following a procedure analogous to Example 27, from the carboxylic acid (6b, 390 mg, 1.41 mmol) of Example 9 or 16 and tert-butyl(3-(aminooxy)propyl)carbamate (730 mg) described in Reference Example 20, the title compound 398.1 mg was afford (yield 63%).

Sources & evidence

ORD record
ord-be328e5ccff54e46b74ad466b3db8d57
Source dataset
uspto-grants-2015_11
Patent number
US09181250B2

Reaction notes

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