HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ferulic Acid → Sitagliptin Ferulate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ferulic Acid | HCID 445858 | — |
| Reactant | Sitagliptin | HCID 4369359 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Sitagliptin Ferulate | HCID 178490572 | — |
Reaction Steps
Sitagliptin free base (0.25 gms) and ferulic acid (0.12 gms) were dissolved in ethyl acetate (2 ml) at 60° C. and the resultant solution was left for slow solvent evaporation at room temperature for 30 hours. Precipitated solids were filtered off and suck dried to obtain the title compound. Yield: 0.31 gms.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181256B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-3ca46e6679cf4afd89e71deded5b58bd |
| Source note | uspto-grants-2015_11 |