反应详情

Sitagliptin free base (2.0 gms) and coumaric acid (0.80 gms) were dissolved in acetonitrile (15 ml) at 60° C. to 65° C. and cooled the solution to −10° C. to −5° C. over a period of 6 hours. Precipitated solids were filtered and dried at 50° C. to 55° C. for 6 hours to obtain the title compound. Yield: 1.62 gms.

1. temperaturecooled the solution to −10° C. to −5° C. over a period of 6 hours
2. customPrecipitated solids
3. filtrationwere filtered
4. customdried at 50° C. to 55° C. for 6 hours