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Diisopropyl Ether → HCID 178511829、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropyl Ether | HCID 7914 | — |
| 反応物 | P-Coumaric Acid | HCID 637542 | — |
| 反応物 | Sitagliptin | HCID 4369359 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | HCID 178511829 | HCID 178511829 | — |
反応手順
Sitagliptin free base (0.5 gms) and coumaric acid (0.20 gms) were dissolved in methanol (3 ml) at 60° C. to 65° C. and the resultant solution was cooled to room temperature. Isopropyl ether (60 ml) was added to the resultant clear solution and stirred for 2 hours. Precipitated solids were filtered and suck dried for 20 minutes to obtain the title compound. Yield: 0.38 gms.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09181256B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-4e530492328c4223abc317b527971d30 |
| 出典メモ | uspto-grants-2015_11 |