(1,1'-Biphenyl)-4-carboxylic acid → N-(4-(pyridazin-4-yl)benzyl)biphenyl-4-carboxamide

Participants

Reaction Steps

To a mixture of (4-(pyridazin-4-yl)phenyl)methanamine 1-3 (19 mg, 0.1 mmol), biphenyl-4-carboxylic acid 1-4 (20 mg, 0.1 mmol) and O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluroniumhexafluorophosphate (HATU) (38 mg, 0.1 mmol) in DMF (0.5 mL) was added DIEA (0.052 mL, 0.3 mmol) at room temperature. The mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted into DMSO and purified by HPLC to give N-(4-(pyridazin-4-yl)benzyl)biphenyl-4-carboxamide 1 as a white solid. MS m/z 366.2 (M+1). 1H NMR 400 MHz (DMSO-d6) δ9.59 (m, 1H), 9.21 (dd, 1H), 9.16 (t, 1H), 7.96 (m, 3H), 7.87 (d, 2H), 7.74 (d, 2H), 7.69 (m, 2H), 7.47-7.41 (m, 4H), 7.37 (m, 1H), 4.52 (d, 2H).

Provenance & Evidence