HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 67208668, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-(3-fluorophenyl)benzoic Acid | HCID 2782686 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 43528580 | HCID 43528580 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67208668 | HCID 67208668 | — |
Reaction Steps
To a mixture of 3′-fluorobiphenyl-4-carboxylic acid 8-5 (51 mg, 0.24 mmol), (6-thiomorpholinopyridin-3-yl)methanamine 8-4 (45 mg, 0.21 mmol) and O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluroniumhexafluorophosphate (HATU) (91 mg, 0.24 mmol) in DMF (1.0 mL) was added DIEA (0.1 mL, 0.64 mmol) at room temperature. The mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted into DMSO and purified by HPLC to give 3′-fluoro-N-((6-thiomorpholinopyridin-3-yl)methyl)biphenyl-4-carboxamide 8-6. MS m/z 408.2 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181235B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-ff5a067dd1884e4f889e6f50b1f15def |
| Source note | uspto-grants-2015_11 |