Trifluoroacetic acid → HCID 67208671, compound

Participants

Reaction Steps

The crude tert-butyl 4-(5-((3-fluoro-4-(2-methylpyridin-4-yl)benzyl)carbamoyl)pyridin-2-yl)piperazine-1-carboxylate 20-2 in dichloromethane (2 mL) was treated with trifluoroacetic acid (TFA, 0.5 mL), and the solution was stirred overnight at room temperature. Evaporation under reduced pressure (with the addition of some toluene to aid evaporation of the residual TFA) followed by lyophilization gave crude N-(3-fluoro-4-(2-methylpyridin-4-yl)benzyl)-6-(piperazin-1-yl)nicotinamide 20-3.

Provenance & Evidence