Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Amino-3-methylbutan-1-ol → 1-(4-Hydroxy-2-methylbutan-2-yl)-3-{4-[(trifluoromethyl)sulfanyl]phenyl}urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Amino-3-methylbutan-1-ol | HCID 641000 | — |
| 반응물 | 1-Isocyanato-4-[(trifluoromethyl)sulfanyl]benzene | HCID 2733392 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-(4-Hydroxy-2-methylbutan-2-yl)-3-{4-[(trifluoromethyl)sulfanyl]phenyl}urea | HCID 90014359 | 95% |
반응 단계
To a solution of 3-amino-3-methyl-butan-1-ol (941 mg, 9.12 mmol) in 10 mL THF was added 4-(trifluoromethylthio)phenylisocyanate (2.0 g, 9.12 mmol). The reaction was stirred at ambient temperature for 16 h. The solution was concentrated and subjected to a hot filtration with CH2Cl2 to give solid 1-(4-hydroxy-2-methylbutan-2-yl)-3-{4-[(trifluoromethyl)sulfanyl]phenyl}urea (95%). LCMS [M+H]+=323.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09181261B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-5264696445744027940e6eec42e12c59 |
| 출처 메모 | uspto-grants-2015_11 |