HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-2-methyl-1-propanol → 1-(1-Hydroxy-2-methylpropan-2-yl)-3-[4-(trifluoromethoxy)phenyl]urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-2-methyl-1-propanol | HCID 11807 | — |
| Reactant | p-(Trifluoromethoxy)phenyl isocyanate | HCID 92298 | — |
| Reactant | 4,4-dimethyl-3-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-1-{4-[(trifluoromethyl)sulfanyl]phenyl}tetrahydropyrimidin-2(1H)-one | HCID 72204423 | — |
| Product | 1-(1-Hydroxy-2-methylpropan-2-yl)-3-[4-(trifluoromethoxy)phenyl]urea | HCID 90014105 | — |
Reaction Steps
1-(1-hydroxy-2-methylpropan-2-yl)-3-[4-(trifluoromethoxy)phenyl]urea was prepared similar to compound 5, but the following reagents were used: 2-amino-2-methyl-1-propanol and 4-(trifluoromethoxy)phenylisocyanate. LCMS [M+H]+=293.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181261B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-8681fdd4225a46349b7174c2342a94ca |
| Source note | uspto-grants-2015_11 |