HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,4-dimethyl-3-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-1-{4-[(trifluoromethyl)sulfanyl]phenyl}tetrahydropyrimidin-2(1H)-one → 4,4-Dimethyl-1-[4-(trifluoromethoxy)phenyl]imidazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,4-dimethyl-3-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-1-{4-[(trifluoromethyl)sulfanyl]phenyl}tetrahydropyrimidin-2(1H)-one | HCID 72204423 | — |
| Reactant | 1-(1-Hydroxy-2-methylpropan-2-yl)-3-[4-(trifluoromethoxy)phenyl]urea | HCID 90014105 | — |
| Product | 4,4-Dimethyl-1-[4-(trifluoromethoxy)phenyl]imidazolidin-2-one | HCID 90014293 | — |
Reaction Steps
4,4-dimethyl-1-[4-(trifluoromethoxy)phenyl]imidazolidin-2-one was prepared similar to procedure for compound 5, using 1-(1-hydroxy-2-methylpropan-2-yl)-3-[4-(trifluoromethoxy)phenyl]urea. 1H NMR (399 MHz, CDCl3): δ 7.26 (s, 2 H); 7.12 (d, J=8.3 Hz, 2 H); 4.09 (s, 2 H); 1.37 (s, 6 H). LCMS [M+H]+=275.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181261B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-b1360f9b279f417994865e1d8a61871d |
| Source note | uspto-grants-2015_11 |