2-[3-(Chloromethyl)phenyl]-1,3-thiazole → 2-Imidazolidinone, 4,4-dimethyl-3-[[3-(2-thiazolyl)phenyl]methyl]-1-[4-(trifluoromethoxy)phenyl]-

Participants

Role	Name	HCID	Charge
Reactant	2-[3-(Chloromethyl)phenyl]-1,3-thiazole	HCID 18525728	—
Reactant	4,4-dimethyl-3-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-1-{4-[(trifluoromethyl)sulfanyl]phenyl}tetrahydropyrimidin-2(1H)-one	HCID 72204423	—
Reactant	4,4-Dimethyl-1-[4-(trifluoromethoxy)phenyl]imidazolidin-2-one	HCID 90014293	—
Product	2-Imidazolidinone, 4,4-dimethyl-3-[[3-(2-thiazolyl)phenyl]methyl]-1-[4-(trifluoromethoxy)phenyl]-	HCID 72206303	—

Reaction Steps

4,4-dimethyl-3-[3-(1,3-thiazol-2-yl)benzyl]-1-[4-(trifluoromethoxy)phenyl]imidazolidin-2-one was prepared similar to procedure for compound 5, using the following reagents: 4,4-dimethyl-1-[4-(trifluoromethoxy)phenyl]imidazolidin-2-one and 2-[3-(chloromethyl)phenyl]-1,3-thiazole. 1H NMR (400 MHz, CDCl3): δ 7.94 (s, 1 H); 7.87-7.78 (m, 2 H); 7.58 (d, J=8.6 Hz, 2 H); 7.45 (d, J=7.7 Hz, 1 H); 7.38 (t, J=7.6 Hz, 1H); 7.32 (d, J=3.2 Hz, 1 H); 4.50 (s, 2 H); 3.56 (s, 2 H); 1.28 (s, 6 H). LCMS [M+H]+=448.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09181261B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-93fedf714c004843b4bcd86c74c42e71
Source note	uspto-grants-2015_11