4-Tert-Butylaniline → HCID 44452554, compound

Participants

Reaction Steps

To a solution of 4-tert-butylaniline (1.0 g, 1.07 mmol) in 5 mL toluene was added 3-chloropropylisocyanate (0.69 mL, 6.70 mmol). The reaction was allowed to stir at ambient temperature for 16 h. The reaction was partitioned between saturated NaHCO3 and ethylacetate. The organics were washed with water and brine, then dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel chromatography to give 1-(4-tert-butylphenyl)-3-(3-chloropropyl)urea (31%). LCMS [M+H]+=269.2.

Provenance & Evidence