Hydrogen Peroxide → HCID 118492062, compound

Participants

Reaction Steps

To a solution of (S)-N,2-dimethyl-N-((R)-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)phenyl)allyl)propane-2-sulfinamide (800 mg, 1.8 mmol) and NaOH (144 mg, 3.6 mmol) in THF (10 mL), was added H2O2 (122 mg, 3.6 mmol) at 0° C. The reaction mixture was allowed to warm to room temperature and stirred for 2 h. After quenched with water, the resulting mixture was extracted with EtOAc. The organic layer was washed with brine, dried over anhydrous Na2SO4. and then concentrated to give the title compound (500 mg, yield: 83%); m/z (ES+): 336 [M+H]+.

Provenance & Evidence