Sulfuric Acid → HCID 178526765, compound

HRID 711359Notes

Reaction equation

HRID 711359 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2[OH:12].OS(O)(=O)=O.[N+:18]([O-])([O-:20])=[O:19].[K+]>>[Cl:1][C:2]1[N:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([N+:18]([O-:20])=[O:19])=[C:5]2[OH:12]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 24434Potassium NitrateHCID 178516422HCID 178516422, compound

Product 1

HCID 178526765HCID 178526765, compoundYield 90%

Conditions

Temperature
100 °C

Procedure

6-chloro-1,5-naphthyridin-4-ol (1.45 g, 8 mmol) was added to ice-cooled conc. H2SO4 (15 mL) and followed by the addition of KNO3 (1.62 g, 16 mmol) slowly at 0° C. The mixture was heated to 100° C. for 1 h, and then was poured into ice-water. The precipitate was collected and dried in vacuo to afford 6-chloro-3-nitro-1,5-naphthyridin-4-ol as a solid in 90% yield (1.97 g).

Workup

  1. customThe precipitate was collected
  2. customdried in vacuo

Sources & evidence

ORD record
ord-0a06517aa3784c61ab9f30fc1323133b
Source dataset
uspto-grants-2015_11
Patent number
US09181264B2

Reaction notes

Loading…