Cyclopropanecarboxylic acid → N'-(7-bromoquinoxalin-2-yl)cyclopropanecarbohydrazide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Cyclopropanecarboxylic acid	HCID 15655	—
Edukt	Diisopropylethylamine	HCID 81531	—
Edukt	7-Bromo-2-hydrazinylquinoxaline	HCID 5200265	—
Edukt	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Lösungsmittel	Dimethylformamide	HCID 6228	—
Lösungsmittel	Ethyl Acetate	HCID 8857	—
Produkt	N'-(7-bromoquinoxalin-2-yl)cyclopropanecarbohydrazide	HCID 66803436	—

Reaktionsschritte

To the solution of 7-bromo-2-hydrazinylquinoxaline (200 mg, 0.83 mmol) in DMF (3 mL) was added HATU (380 mg, 1 mmol), DIPEA (0.205 mL, 1 mmol) and cyclopropanecarboxylic acid (71 mg, 0.83 mmol). After stirring at r.t. for 5 h, the mixture was diluted with EtOAc. The organic layer was washed with water for three times, then concentrated to afford N′-(7-bromoquinoxalin-2-yl)cyclopropane-carbohydrazide as yellow solid which was used directly in the next step. m/z 309 (M+H)+.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09181264B2
Quelldatensatz	uspto-grants-2015_11
ORD ID	ord-4404a10cb1fb4730b7ea7712e16e4625
Quellennotiz	uspto-grants-2015_11