Lithium Hydroxide → HCID 86690697, compound

Participants

Reaction Steps

To a solution of (S)-1-(4-(8-chloro-1H-[1,2,3]triazolo[4,5-c][1,5]naphthyridin-1-yl)piperidin-1-yl)-1-oxopropan-2-yl acetate (1.2 g, 2.97 mmol) in a mixture of THF (30 mL) and MeOH (30 mL), was added LiOH (650 mg, 14.9 mmol) drop-wise. The mixture was stirred at room temperature for 3 h. After concentration in vacuo, the residue was diluted with water and the pH was adjusted to 7 with 2N HCl. The resulting mixture was concentrated and the precipitate was collected by filtration, washed with H2O, and dried in vacuo to afford (S)-1-(4-(8-chloro-1H-[1,2,3]triazolo[4,5-c][1,5]naphthyridin-1-yl)piperidin-1-yl)-2-hydroxypropan-1-one as yellow solid. The crude product was used in next step without further purification. (918 mg, yield 85.4%). MS (m/z): 361 (M+H)+.

Provenance & Evidence