Potassium Carbonate → 1-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-1H-[1,2,3]triazolo[4,5-c][1,5]naphthyridin-1-yl)piperidin-1-yl)-2-methylpropan-1-one

Participants

Reaction Steps

A mixture of 1-(4-(8-chloro-1H-[1,2,3]triazolo[4,5-c][1,5]naphthyridin-1-yl)piperidin-1-yl)-2-methylpropan-1-one (60 mg, 0.17 mmol), 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridin-2-amine (53 mg, 0.18 mmol), K2CO3 (70 mg, 0.51 mmol) and Pd(dppf)Cl2 (6 mg) in dioxane/H2O (3:1, 4 mL) was stirred and microwaved at 160° C. for 0.5 h. The solvent was removed, and the residue was purified by ISCO (MeOH/H2O=20%-80%) to afford 1-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-1H-[1,2,3]triazolo[4,5-c][1,5]naphthyridin-1-yl)piperidin-1-yl)-2-methylpropan-1-one as white solid (46 mg). 1HNMR (400 MHz, dmso) δ 9.61 (s, 1H), 9.21 (d, J=2.1 Hz, 1H), 8.66 (dd, J=12.5, 5.5 Hz, 2H), 8.55 (d, J=8.9 Hz, 1H), 7.10 (s, 2H), 6.17-6.01 (m, 1H), 4.78-4.59 (m, 1H), 4.35-4.26 (m, 1H), 3.40-3.37 (m, 2H), 3.05-2.97 (m, 1H), 2.93-2.82 (m, 1H), 2.64-2.52 (m, 1H), 2.39-2.21 (m, 1H), 2.16-1.96 (m, 1H), 1.07 (s, 6H). MS (m/z): 485 (M+H)+.

Provenance & Evidence