反应详情

A mixture of tert-butyl 4-(2-(7-bromoquinoxalin-2-yl)hydrazinecarbonyl)piperidine-1-carboxylate (900 mg, 2.0 mmol) in AcOH (10 mL) was refluxed overnight. Then the solvent was removed, and the residue was purified by ISCO (MeOH/H2O=20%-90%) to afford 8-bromo-1-(piperidin-4-yl)[1,2,4]triazolo[4,3-a]quinoxaline as a pale yellow solid (550 mg, yield 83.0%). MS (m/z): 332 (M+H)+.

1. temperaturewas refluxed overnight
2. customThen the solvent was removed
3. customthe residue was purified by ISCO (MeOH/H2O=20%-90%)