2-Chloropyridine → HCID 817760, compound

HRID 711393Notes

Reaction equation

HRID 711393 reaction equation
[C:1]1([S:7][C:8](Cl)(Cl)Cl)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:13]1[CH:18]=[CH:17][CH:16]=C[N:14]=1>C(N)=O>[C:1]1([S:7][C:8]2[CH:16]=[CH:17][CH:18]=[CH:13][N:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 79772-ChloropyridineHCID 23273522[(Trichloromethyl)sulfanyl]benzene

Product 1

HCID 817760HCID 817760, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 713FormamideSolvent

Conditions

Temperature
75 °C

Procedure

A solution of phenyl(trichloromethyl)sulfane (0.25 g, 1.099 mmol) in formamide (16.40 ml) was degassed with nitrogen and treated with 2-chloropyridine (0.114 ml, 1.209 mmol). The reaction solution was heated at 75° C. overnight. GCMS indicates a yield of 62% of 2-(phenylthio)pyridine, and a 22% byproduct of disulfide.

Sources & evidence

ORD record
ord-77b2141056c642278becf04dea463df3
Source dataset
uspto-grants-2015_11
Patent number
US09181270B2

Reaction notes

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