2,4-Dichloro-5-(2-((trichloromethyl)thio)phenyl)pyrimidine → 2-Chlorobenzo[4,5]thieno[2,3-d]pyrimidine

Participants

Reaction Conditions

Reaction Steps

A solution of 2,4-dichloro-5-(2-((trichloromethyl)thio)phenyl)pyrimidine (12.5 g, 33.4 mmol) in formamide (498 ml) was degassed with nitrogen and heated at 60° C. overnight. The reaction solution was cooled to room temperature, diluted with water, filtered and washed with water and a small amount of cold ethanol. White precipitate was recrystallized from EtOH to afford 5.0 g (68% yield) of 2-chlorobenzo[4,5]thieno[2,3-d]pyrimidine as white needles.

Provenance & Evidence