Methanesulfonyl chloride → 2-(7-Iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl)ethyl methanesulfonate

Participants

Reaction Steps

Mesyl chloride (0.172 g, 1.50 mmol) was added to an ice-cooled stirred solution of 4-(2-hydroxyethyl)-7-iodo-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one (0.230 g, 0.75 mmol) and DIPEA (0.291 g, 2.25 mmol) in DCM (5 ml). The reaction mixture was stirred at room temperature under N2 for 1 h and then it was portioned between DCM and saturated NaHCO3 solution. The title compound was isolated by precipitation from the organic layer as a white solid (0.202 g, 0.52 mmol, 70%).

Provenance & Evidence