Hydrochloric Acid → HCID 89487374, compound

Participants

Reaction Steps

In a two necked flask cooled in an ice bath and under argon atmosphere, dimethyl(2S)-2-(1H-pyrrol-1-yl)butanedioate (20.3 mmol, 4.3 g) was dissolved in 50 ml of dry THF. LiAlH4 (42 ml, 1 M in THF) was cautiously added and the reaction was let warm up at room temperature. When the reaction was completed, it was cooled again to 0° C. and acidified with 2M HCl. Water and AcOEt were added to the quenched reaction and the organic layer was extracted with brine. The crude residue was purified by chromatography on silica gel (eluent: DCM/MeOH:95/5) to give the product as a colourless oil (2.0 g, 63% yield).

Provenance & Evidence