Iodine → HCID 86732561, compound

Participants

Reaction Steps

Iodine (450 mg 1.77 mmol) was added portion wise to a solution of tert-butyl(2-{1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate (780 mg 1.77 mmol) and silver trifluoroacetate (392 mg, 1.77 mmol) in dry DCM (100 ml), at 5° C. The reaction mixture was stirred at the same temperature for 1 hour, then the ice bath removed and left to warm to rt (1 h). The solid was filtered, the organic phase washed with Na2S2O5 (5% aq. solution) until decolouration occurred and finally washed with water. The organic was dried over Na2SO4 to obtain the title compound 1.0 g (99%) as a white solid.

Provenance & Evidence