Methanesulfonyl chloride → HCID 71523273, compound

Participants

Reaction Steps

40 mg (0.096 mmol) of 1(4S)-4-(2-aminoethyl)-6-phenyl)-7-[3-(trifluoromethoxy)phenyl]-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one hydrochloride were dissolved in 3 ml of DCM. To the obtained solution, 15 μl (0.192 mmol) of methanesulfonyl chloride, 57 μl (0.33 mmol) of DIPEA, were added. The mixture was stirred at rt for 2 hours, the solution was portioned between ethyl acetate and saturated aqueous solution of NaHCO3, the organic layer was washed with brine, dried over Na2SO4 and evaporated under vacuum. The product was purified by HPLC preparative method 2 and isolated as a off-white solid 24 mg (51%) as a white solid.

Provenance & Evidence