(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine → HCID 58317729, compound

Participants

Reaction Conditions

Reaction Steps

A tube containing 4,6-dichloro-2-(2,4-dimethoxybenzyl)-7-fluoro-1H-pyrrolo[3,4-c]pyridin-3(2H)-one (300 mg, 0.808 mmol) and (S)-tert-butyl pyrrolidin-3-ylcarbamate (301 mg, 1.616 mmol) dissolved in ACN (4 mL) was sealed and heated at 100° C. for 2 d. The reaction mixture was concentrated and dissolved in EtOAc (20 mL) and washed with saturated aq NaHCO3 (10 mL) and brine (10 mL). The organic extracts were dried over Na2SO4 and evaporated to give a crude product, which was purified via preparative HPLC. Pure fractions were collected and evaporated to give the title compound (235 mg, 55.8%). [M+H] calc'd for C25H30ClFN4O5, 521. found, 521.

Provenance & Evidence