Thiourea → HCID 25222914, compound

HRID 711645Notes

Reaction equation

HRID 711645 reaction equation
Cl[C:2]1[N:11]=[C:10]([N:12]([CH3:14])[CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.NC(N)=[S:17]>>[CH3:13][N:12]([CH3:14])[C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3][C:2](=[S:17])[N:11]=1

Participants

3

Reactant 2

HCID 2723790ThioureaHCID 126843422-Chloro-N,N-dimethylquinazolin-4-amine

Product 1

HCID 25222914HCID 25222914, compound

Procedure

Prepared as in Example 46 from 2-chloro-N,N-dimethylquinazolin-4-amine (Example 40) and thiourea. 1H NMR (400 MHz, DMSO-d6) δ 3.31 (s, 6H), 7.24-7.19 (m, 1H), 7.40-7.38 (m, 1H), 7.65-7.61 (m, 1H), 8.00 (d, J=8.0 Hz, 1H), 12.35 (s, 1H). MS 206 (MH+).

Sources & evidence

ORD record
ord-8bc94637fe5d4cf5aebcc337c96dc23a
Source dataset
uspto-grants-2015_11
Patent number
US09181276B2

Reaction notes

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