Chlorosulfamic acid → HCID 67399212, compound

HRID 711855Notes

Reaction equation

HRID 711855 reaction equation
[C:1]([O:4][CH2:5][C:6]([CH3:19])([CH3:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH2:15])[C:10]=1[C:16]#[N:17])(=[O:3])[CH3:2].[S:20](Cl)(=[O:23])(=[O:22])[NH2:21]>>[C:1]([O:4][CH2:5][C:6]([CH3:19])([CH3:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][S:20](=[O:23])(=[O:22])[NH2:21])[C:10]=1[C:16]#[N:17])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 24499Chlorosulfamic acidHCID 66747072HCID 66747072, compound

Product 1

HCID 67399212HCID 67399212, compoundYield 60%

Procedure

Prepared as in Example 215a from 3-(3-amino-2-cyanophenoxy)-2,2-dimethylpropyl acetate (Example 233b) and sulfamoyl chloride in 60% yield. 1H NMR (400 MHz, DMSO-d6) δ 0.99 (s, 6H), 1.98 (s, 3H), 3.85 (s, 2H), 3.91 (s, 2H), 6.91 (d, J=8.4 Hz, 1H), 7.12 (d, J=8.0 Hz, 1H), 7.23 (s, 2H), 7.52 (t, J=8.0 Hz, 1H), 9.45 (s, 1H).

Sources & evidence

ORD record
ord-efeb929539c649688ef782effc5115ba
Source dataset
uspto-grants-2015_11
Patent number
US09181276B2

Reaction notes

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