2-Amino-6-fluorobenzonitrile → HCID 66746233, compound

HRID 711886Notes

Reaction equation

HRID 711886 reaction equation
[OH:1][CH2:2][C:3]([CH3:19])([CH3:18])[CH2:4][NH:5][C:6]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)=[O:7].[NH2:20][C:21]1[CH:28]=[CH:27][CH:26]=[C:25](F)[C:22]=1[C:23]#[N:24]>>[NH2:20][C:21]1[C:22]([C:23]#[N:24])=[C:25]([CH:26]=[CH:27][CH:28]=1)[O:1][CH2:2][C:3]([CH3:19])([CH3:18])[CH2:4][NH:5][C:6]([NH:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([O:16][CH3:17])=[CH:14][CH:15]=1)=[O:7]

Participants

3

Reactant 2

HCID 5226592-Amino-6-fluorobenzonitrileHCID 667472421-(3-Hydroxy-2,2-dimethylpropyl)-3-(4-methoxybenzyl)urea

Product 1

HCID 66746233HCID 66746233, compoundYield 60%

Procedure

Prepared as in Example 215b (Method B) from 1-(3-hydroxy-2,2-dimethylpropyl)-3-(4-methoxybenzyl)urea (Example 252c) and 2-amino-6-fluorobenzonitrile in 60% yield. MS 383 (MH+).

Sources & evidence

ORD record
ord-3c271a7fe3354cecb4d1e22c0afb3aee
Source dataset
uspto-grants-2015_11
Patent number
US09181276B2

Reaction notes

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