HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-((2-Methylcyclopropyl)methoxy)-6-nitrobenzonitrile → 2-Amino-6-((2-methylcyclopropyl)methoxy)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-((2-Methylcyclopropyl)methoxy)-6-nitrobenzonitrile | HCID 66746593 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol ethylacetate | HCID 21584252 | — |
| Product | 2-Amino-6-((2-methylcyclopropyl)methoxy)benzonitrile | HCID 66746901 | 79.1% |
Reaction Steps
A solution of 2-((2-methylcyclopropyl)methoxy)-6-nitrobenzonitrile (example 254c) (0.29 g, 1.25 mmol) in EtOAc/EtOH 1:1 (30 mL) was hydrogenated in an H-cube apparatus using 10% Pd/C as catalyst. The solution was evaporated to give 2-amino-6-((2-methylcyclopropyl)methoxy)benzonitrile (0.20 g, 79%) as a yellow oil. MS 203 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181276B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-ba0fb513c5dc40b09bd285c1a908a747 |
| Source note | uspto-grants-2015_11 |