1-(2-Hydroxyethyl)-2-pyrrolidinone → 2-Nitro-6-(2-(2-oxopyrrolidin-1-yl)ethoxy)benzonitrile

HRID 711892Notes

Reaction equation

[OH:1][CH2:2][CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][C:5]1=[O:9].[N+:10]([C:13]1[CH:20]=[CH:19][CH:18]=[C:17]([N+]([O-])=O)[C:14]=1[C:15]#[N:16])([O-:12])=[O:11]>>[N+:10]([C:13]1[CH:20]=[CH:19][CH:18]=[C:17]([O:1][CH2:2][CH2:3][N:4]2[CH2:8][CH2:7][CH2:6][C:5]2=[O:9])[C:14]=1[C:15]#[N:16])([O-:12])=[O:11]

Participants

Reactant 2

HCID 769801-(2-Hydroxyethyl)-2-pyrrolidinone

HCID 520718Dinitrobenzonitrile

Product 1

HCID 667467332-Nitro-6-(2-(2-oxopyrrolidin-1-yl)ethoxy)benzonitrileYield 74%

Procedure

Prepared as in Example 166d from 1-(2-hydroxyethyl)pyrrolidin-2-one and 2,6-dinitrobenzonitrile in 74% yield. MS 276 (MH+).

Sources & evidence

ORD record: ord-9d569c28cb0a411b8b52470d7050b363
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09181276B2

Reaction notes

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