HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-6-bromobenzonitrile → HCID 67400820, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-6-bromobenzonitrile | HCID 9813038 | — |
| Reactant | [(1R,2R)-2-(Methoxymethyl)cyclopropyl]boronic acid | HCID 57416267 | — |
| Product | HCID 67400820 | HCID 67400820 | 64% |
Reaction Steps
Prepared as in Example 270a from (±)-trans-2-(methoxymethyl)cyclopropylboronic acid (example 271b) and 2-amino-6-bromobenzonitrile in 64% yield as a yellowish brown waxy solid. 1H NMR (400 MHz, DMSO-d6) δ 0.932 (m, 2H), 1.341 (m, 1H), 1.879 (m, 1H), 2.324 (s, 3H), 3.351 (d, J=6 Hz, 2H), 5.896 (br. s, 2H), 6.148 (d, J=8 Hz, 1H), 6.550 (d, J=8 Hz, 1H), 7.130 (t, J=8 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181276B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-abc608da42e645fca79b155136c54d2e |
| Source note | uspto-grants-2015_11 |