HCID 66746431, compound → HCID 66746435, compound

HRID 711916Notes

Reaction equation

HRID 711916 reaction equation
[C:1]([O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-])=O)[C:15]=1[C:23]#[N:24])(=[O:3])[CH3:2]>CCO.[Pd]>[C:1]([O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([NH2:20])[C:15]=1[C:23]#[N:24])(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 66746431HCID 66746431, compound

Product 1

HCID 66746435HCID 66746435, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 8-(2-cyano-3-nitrophenoxy)octyl acetate (802 μmol, 268 mg) (Example 274c) in EtOH (15 mL) was hydrogenated in an H-cube apparatus using 10% Pd/C as catalyst. The solution was evaporated to give 8-(3-amino-2-cyanophenoxy)octyl acetate (244 mg, 244 mg). MS 305 (MH+).

Workup

  1. customThe solution was evaporated

Sources & evidence

ORD record
ord-e71df37c7a464a50b3831b3143528f3b
Source dataset
uspto-grants-2015_11
Patent number
US09181276B2

Reaction notes

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