反应详情

温度

90 °C

A mixture of trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl methanesulfonate (0.12 g, 0.32 mmol) and sodium cyanide (0.061 g, 1.2 mmol) in dimethyl sulfoxide (1 mL) was stirred at 90° C. for 6 h. After dilution with EtOAc, the resulting mixture was washed with sat. NaHCO3 solution, water and brine, and then concentrated. The residue was purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane) to give the desired product (32 mg). LCMS calculated for C14H15N4O2S (M+H)+: m/z=303.1. Found: 303.0.

1. washAfter dilution with EtOAc, the resulting mixture was washed with sat. NaHCO3 solution, water and brine
2. concentrationconcentrated
3. customThe residue was purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane)