Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 711966생성일: 2026년 10월 25일
Diisopropylethylamine → tert-Butyl 3-hydroxy-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]piperidine-1-carboxylate
https://huagongshe.com/reaction/711966
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 7-Chloro-6-nitrothieno[3,2-b]pyridine | HCID 14207950 | — |
| 반응물 | tert-Butyl 4-amino-3-hydroxypiperidine-1-carboxylate | HCID 21874161 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | tert-Butyl 3-hydroxy-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]piperidine-1-carboxylate | HCID 86717435 | 90.5% |
반응 단계
A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.61 g, 2.8 mmol) (Example 1, Step 2), tert-butyl 4-amino-3-hydroxypiperidine-1-carboxylate (from Aurora, 0.95 g, 4.4 mmol) and N,N-diisopropylethylamine (0.99 mL, 5.7 mmol) in isopropyl alcohol (7.4 mL) was heated at 90° C. for 2 h. The resulting mixture was diluted with water. The precipitate was collected by filtration, washed with water and air-dried to give the desired product (1 g, 89%). LCMS calculated for C17H23N4O5S (M+H)+: m/z=395.1. Found: 395.0.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09181271B2 |
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| 출처 데이터셋 | uspto-grants-2015_11 |
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| ORD ID | ord-925d38b8a7f1433692510fe11b75bf0a |
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| 출처 메모 | uspto-grants-2015_11 |
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