反应详情

A mixture of {trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (1.0 g, 3.2 mmol) and 10% palladium on carbon (0.3 g, 0.3 mmol) in methanol (30 mL) was hydrogenated under balloon pressure of H2 at room temperature for 5 h. The reaction mixture was filtered. The filtrate was concentrated, diluted with dichlormethane, dried over MgSO4, and concentrated. The residue was purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane) to give the desired product. (0.63 g, 70%). LCMS calculated for C15H19N4S (M+H)+: m/z=287.1. Found: 287.1.

1. filtrationThe reaction mixture was filtered
2. concentrationThe filtrate was concentrated
3. additiondiluted with dichlormethane
4. dry with materialdried over MgSO4
5. concentrationconcentrated
6. customThe residue was purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane)