Acetonitrile → HCID 86717466, compound

HRID 712007Notes

Reaction equation

HRID 712007 reaction equation
[OH:1][C@@H:2]([C:4]1[N:15]([C@@H:16]2[CH2:21][O:20][C@@H:19]([CH2:22][C:23]#[N:24])[CH2:18][CH2:17]2)[C:7]2=[C:8]3[S:14][CH:13]=[CH:12][C:9]3=[N:10][CH:11]=[C:6]2[N:5]=1)[CH3:3].C(#N)C>O>[OH2:1].[OH:1][C@@H:2]([C:4]1[N:15]([C@@H:16]2[CH2:21][O:20][C@@H:19]([CH2:22][C:23]#[N:24])[CH2:18][CH2:17]2)[C:7]2=[C:8]3[S:14][CH:13]=[CH:12][C:9]3=[N:10][CH:11]=[C:6]2[N:5]=1)[CH3:3]

Participants

4

Reactant 2

HCID 6342AcetonitrileHCID 73776047HCID 73776047, compound

Product 1

HCID 86717466HCID 86717466, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

((2R,5S)-5-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)acetonitrile (52 mg, 0.15 mmol) from Example 20 was crystallized from a mixture of acetonitrile (8 mL) and water (4 mL). The resulting colorless prism crystal collected was suitable for X-ray crystal structure analysis.

Workup

  1. customThe resulting colorless prism crystal collected

Sources & evidence

ORD record
ord-e5699e18dbde40a98a58766474768e2f
Source dataset
uspto-grants-2015_11
Patent number
US09181271B2

Reaction notes

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