N-Iodosuccinimide → HCID 178516695, compound

HRID 712012Notes

Reaction equation

HRID 712012 reaction equation
[S:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][C:8]=2[OH:10])[CH:3]=[CH:2]1.[I:11]N1C(=O)CCC1=O>C(#N)C>[I:11][C:7]1[C:8]([OH:10])=[C:9]2[S:1][CH:2]=[CH:3][C:4]2=[N:5][CH:6]=1

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 5074765Thieno[3,2-b]pyridin-7-ol

Product 1

HCID 178516695HCID 178516695, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of thieno[3,2-b]pyridin-7-ol (from Aldrich) (0.54 g, 3.6 mmol) and N-iodosuccinimide (0.88 g, 3.9 mmol) in acetonitrile (10 mL) was heated at reflux overnight. The mixture was concentrated under reduced pressure to give the desired product which was used in the next step without further purification. LCMS calculated for C7H5INOS (M+H)+: m/z=277.9. Found: 277.8.

Workup

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-ea054b2c91ae4a20a0453632b40f7930
Source dataset
uspto-grants-2015_11
Patent number
US09181271B2

Reaction notes

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